Understanding how gene regulatory regions in the nucleus are formed and maintained during development
Developmental regulation of nuclear domains
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-10873827
This study looks at how both a mother’s genes and the genes of a developing embryo work together to control important areas in the cell's nucleus that help manage gene activity, which could help us better understand genetic disorders and developmental diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10873827 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which maternal and zygotic factors work together to establish and maintain gene regulatory domains in the nucleus of developing embryos. By focusing on the Drosophila histone locus, the study aims to uncover how transcription factors locate and function within these domains, which are crucial for proper gene regulation. The research employs advanced techniques to analyze the interactions between DNA sequences and transcription factors, providing insights into the regulatory signals that guide development and may contribute to disease. Patients may benefit from this knowledge as it could lead to improved understanding of genetic disorders and developmental diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or developmental issues linked to gene regulation.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by developmental disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and lead to new strategies for treating developmental disorders.
How similar studies have performed: Other research has shown success in understanding gene regulation through similar approaches, particularly in model organisms like Drosophila.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIEDER, LEILA ELIZABETH — EMORY UNIVERSITY
- Study coordinator: RIEDER, LEILA ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.