Understanding how gene regulatory elements affect diseases in mice
Development of functional genomic technologies in mice
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11284375
This study is looking at how certain parts of our genes can affect health and disease, using mice to see how changes in these gene regulators might lead to different health issues, which could help us understand and treat these conditions better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11284375 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying and characterizing gene regulatory elements that play a crucial role in human diseases. By developing advanced genomic technologies, the project aims to test the functionality of these elements in living mice, which allows for a better understanding of how mutations can lead to various health conditions. The approach includes high-throughput methods that go beyond traditional cell cultures, enabling researchers to observe the effects of these regulatory elements in real biological contexts. This could lead to insights into the complex interactions between genes and their regulatory sequences.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions that may be influenced by mutations in gene regulatory elements.
Not a fit: Patients with diseases not associated with gene regulatory mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases linked to gene regulatory mutations.
How similar studies have performed: Other research has shown promise in using high-throughput genomic technologies to understand gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: USHIKI, AKI — WASHINGTON UNIVERSITY
- Study coordinator: USHIKI, AKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.