Understanding how gene regulatory elements affect diseases in mice
Official title: Development of functional genomic technologies in mice
Funded at Washington University · NIH-11284375 · Data updated 2026-11-12
This study is looking at how certain parts of our genes can affect health and disease, using mice to see how changes in these gene regulators might lead to different health issues, which could help us understand and treat these conditions better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $224,101 |
| NIH project number | 4R00HG012576-03 |
| Project ID | NIH-11284375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic conditions that may be influenced by mutations in gene regulatory elements.
✕Less likely to help
Patients with diseases not associated with gene regulatory mutations may not benefit from this research.
What this research studies
This research focuses on identifying and characterizing gene regulatory elements that play a crucial role in human diseases. By developing advanced genomic technologies, the project aims to test the functionality of these elements in living mice, which allows for a better understanding of how mutations can lead to various health conditions. The approach includes high-throughput methods that go beyond traditional cell cultures, enabling researchers to observe the effects of these regulatory elements in real biological contexts. This could lead to insights into the complex interactions between genes and their regulatory sequences.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases linked to gene regulatory mutations.
How similar studies have gone: Other research has shown promise in using high-throughput genomic technologies to understand gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Ushiki, Aki — Washington University
- Study coordinator: Ushiki, Aki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.