Understanding how gene regulators control neuron function
Official title: COORDINATE CONTROL OF INDIVIDUAL NEURONAL TRANSCRIPTOMES BY TRANSCRIPTION FACTORS AND RNA BINDING PROTEINS
Funded at University of California Riverside · NIH-10987830 · Data updated 2026-11-12
This study is looking at how certain genes affect the growth and function of individual nerve cells in tiny worms, which can help us understand how our own nerve cells work and communicate.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $334,195 |
| NIH project number | 7R01NS111055-05 |
| Project ID | NIH-10987830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the genetic basis of neuronal function and those affected by neurological conditions.
✕Less likely to help
Patients with conditions unrelated to neuronal function or those not interested in genetic research may not benefit from this research.
What this research studies
This research investigates the unique properties of individual neurons and how specific gene regulatory factors, such as transcription factors and RNA binding proteins, influence their development and function. Using the model organism Caenorhabditis elegans, the study aims to uncover the mechanisms behind the coordinated regulation of neuronal transcriptomes. Advanced genetic techniques, including CRISPR/Cas9 and RNA sequencing, will be employed to analyze how these factors interact at the cellular level. By focusing on single neurons, the research seeks to provide insights into the fundamental processes that govern neuronal behavior and gene expression.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neuronal function and potentially inform treatments for neurological disorders.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding gene regulation in other contexts.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Norris, Adam — University of California Riverside
- Study coordinator: Norris, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.