Understanding how gene regulation works using advanced computational models
Evaluating the utility of cis-regulatory element graphs for modeling gene regulation
['FUNDING_R03'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10776793
This study is exploring how certain parts of our DNA help control gene activity, using computer models to better understand these interactions, which could lead to new insights in genetics and personalized healthcare for everyone.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10776793 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of cis-regulatory elements (CREs) in gene regulation by developing a new computational framework that models CRE-gene interactions as graphs. By utilizing public genomic datasets, the project aims to predict gene expression and understand the mechanisms behind gene regulation. Researchers will employ graph neural networks to analyze these interactions and improve predictions, ultimately enhancing our understanding of how genes are regulated in different biological contexts. This innovative approach could lead to significant advancements in genomics and personalized medicine.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or those interested in the genetic basis of diseases, particularly those related to gene regulation.
Not a fit: Patients with conditions unrelated to gene regulation or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prediction of gene expression, which may enhance personalized treatment strategies for various genetic conditions.
How similar studies have performed: Other research has shown promise in using computational models for gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOORE, JILL ELIZABETH — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: MOORE, JILL ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.