Understanding how gene regulation works in cells
Biophysical modeling of cis-regulatory complexes in transcription and splicing using massively parallel reporter assays
This study is looking at how proteins and DNA work together to control when genes are turned on or off, which is important for understanding how our bodies function and could help develop new treatments for diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-10697342 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between proteins and nucleic acids that control gene expression in various organisms, including humans. By using advanced techniques called massively parallel reporter assays, the researchers aim to create detailed biophysical models of these regulatory complexes. This approach allows for a better understanding of how genes are turned on and off in response to cellular signals, which is crucial for advancing knowledge in basic science and potential therapeutic applications. The findings could lead to breakthroughs in synthetic biology and treatments for human diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that involve dysregulation of gene expression.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may improve treatments for various diseases.
How similar studies have performed: Other research has shown success in understanding gene regulation through similar biophysical modeling approaches, indicating a promising avenue for further exploration.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Kinney, Justin B. — Cold Spring Harbor Laboratory
- Study coordinator: Kinney, Justin B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.