Understanding how gene regulation works in cancer through new molecular principles
Illuminating transcriptional condensates using an integrated approach
This study is looking at how certain proteins work together to control gene activity, which is important for keeping us healthy and can help us understand diseases like cancer, especially by exploring how natural changes in our genes affect these protein groups.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10488968 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of gene regulation, which are crucial for human health and can lead to diseases like cancer when disrupted. It focuses on the formation of transcriptional condensates, which are assemblies of proteins that play a key role in gene expression. By studying naturally occurring mutations associated with cancer, the research aims to uncover how these condensates are formed and regulated, and how they influence gene control during development and disease. This approach combines experimental strategies to manipulate these condensates for deeper insights into their functions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with specific genetic mutations related to cancer that may affect gene regulation.
Not a fit: Patients without genetic mutations impacting gene regulation or those with non-cancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers by targeting the mechanisms of gene regulation.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through similar molecular approaches, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wan, Liling — University of Pennsylvania
- Study coordinator: Wan, Liling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.