Understanding how gene regulation is controlled in three dimensions within cells
Official title: Regulatory Mechanisms Linking Spatial Gene Control and Genome Organization
Funded at Georgetown University · NIH-11092847 · Data updated 2026-11-12
This study is looking at how certain parts of our DNA help control when genes are turned on or off inside our cells, which could lead to new treatments for diseases related to gene activity.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $383,840 |
| NIH project number | 5R35GM150636-03 |
| Project ID | NIH-11092847 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or conditions influenced by gene expression.
✕Less likely to help
Patients with conditions unrelated to gene regulation or expression may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which gene expression is regulated in three-dimensional space within the cell nucleus. It focuses on the role of enhancers, which are non-coding regulatory elements that help turn genes on or off in response to cellular signals. By utilizing advanced sequencing technologies and imaging techniques, the study aims to uncover how these enhancers interact and form complexes that influence gene activity. Patients may benefit from insights gained into gene regulation that could lead to new therapeutic strategies for diseases linked to gene expression.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by improper gene regulation.
How similar studies have gone: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Nair, Sreejith Janardhanan — Georgetown University
- Study coordinator: Nair, Sreejith Janardhanan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.