Understanding how gene regulation is controlled in three dimensions within cells
Regulatory Mechanisms Linking Spatial Gene Control and Genome Organization
['FUNDING_OTHER'] · GEORGETOWN UNIVERSITY · NIH-11092847
This study is looking at how certain parts of our DNA help control when genes are turned on or off inside our cells, which could lead to new treatments for diseases related to gene activity.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11092847 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which gene expression is regulated in three-dimensional space within the cell nucleus. It focuses on the role of enhancers, which are non-coding regulatory elements that help turn genes on or off in response to cellular signals. By utilizing advanced sequencing technologies and imaging techniques, the study aims to uncover how these enhancers interact and form complexes that influence gene activity. Patients may benefit from insights gained into gene regulation that could lead to new therapeutic strategies for diseases linked to gene expression.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or conditions influenced by gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or expression may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by improper gene regulation.
How similar studies have performed: Other research has shown promising results in understanding gene regulation through similar approaches, indicating potential for success in this area.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAIR, SREEJITH JANARDHANAN — GEORGETOWN UNIVERSITY
- Study coordinator: NAIR, SREEJITH JANARDHANAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.