Understanding how gene regulation differs in male and female reproductive cells
Epigenetic gene regulation in the germline
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11089654
This study is looking at how sperm and egg cells develop and how certain changes in our genes can affect this process, which could help us understand and treat genetic issues related to these cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11089654 on ClinicalTrials.gov |
What this research studies
This research investigates the complex processes of sperm and egg development, focusing on how epigenetic mechanisms influence these sexually dimorphic processes. By examining the changes in gene expression and the epigenome during the transition from mitosis to meiosis in germ cells, the research aims to uncover the fundamental principles that govern the formation of functional sperm and eggs. The findings could lead to better understanding and potential treatments for genetic and epigenetic diseases that arise from germline issues.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with a family history of germline-related genetic disorders or those experiencing infertility issues.
Not a fit: Patients who do not have any reproductive health concerns or genetic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved treatments for various genetic and epigenetic disorders affecting reproduction.
How similar studies have performed: Previous research has shown success in understanding epigenetic mechanisms in germline development, indicating that this approach has potential for significant findings.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAMEKAWA, SATOSHI — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: NAMEKAWA, SATOSHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: DNA Injury, Disease, Disorder