Understanding how gene regulation differs in male and female reproductive cells
Epigenetic gene regulation in the germline
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10877805
This study is looking at how sperm and egg cells develop in men and women, focusing on the special changes in genes that happen during this process, to help us better understand reproduction and find new ways to treat related health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10877805 on ClinicalTrials.gov |
What this research studies
This research investigates the complex processes of spermatogenesis and oogenesis, which are the development of sperm and eggs, respectively. By focusing on the epigenetic mechanisms that regulate these processes, the study aims to uncover how these mechanisms differ between males and females. The research employs innovative approaches to analyze gene expression and epigenomic changes during the transition from mitosis to meiosis in germ cells. This work is crucial for understanding the biological foundations of reproduction and the potential development of treatments for genetic and epigenetic diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with known genetic or epigenetic disorders related to reproductive health.
Not a fit: Patients who do not have any reproductive health issues or genetic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for various genetic and epigenetic disorders affecting reproduction and development.
How similar studies have performed: Previous research has shown promising results in understanding epigenetic mechanisms in germline development, indicating that this approach has potential for significant advancements.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAMEKAWA, SATOSHI — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: NAMEKAWA, SATOSHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: DNA Injury, Disease, Disorder