Understanding how gene regulation changes in acute myeloid leukemia
Decoding the Molecular Basis of Dysregulated Cleavage and Polyadenylation in Myeloid Malignancies - Resubmission - 1
['FUNDING_FELLOWSHIP'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10995444
This study is looking at how gene activity changes in acute myeloid leukemia (AML) by comparing cancerous blood stem cells to healthy ones from the same person, with the goal of finding new ways to improve treatment for AML.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10995444 on ClinicalTrials.gov |
What this research studies
This research investigates how the regulation of gene expression is altered in acute myeloid leukemia (AML) by focusing on a process called alternative polyadenylation. Using advanced techniques like single-cell RNA sequencing, the study aims to compare the gene regulation in cancerous hematopoietic stem cells to that in healthy cells from the same patient. By identifying specific changes in gene regulation, the research seeks to uncover the underlying mechanisms driving AML and potentially improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who are willing to provide samples for analysis.
Not a fit: Patients with other types of blood cancers or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into AML that may improve diagnosis and treatment options for patients.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in other cancers, suggesting that this approach may yield valuable insights for AML as well.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOWALSKI, MADELINE HEIDI — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: KOWALSKI, MADELINE HEIDI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.