Understanding how gene regulation changes in acute myeloid leukemia
Official title: Decoding the Molecular Basis of Dysregulated Cleavage and Polyadenylation in Myeloid Malignancies - Resubmission - 1
Funded at New York University School of Medicine · NIH-10995444 · Data updated 2026-11-12
This study is looking at how gene activity changes in acute myeloid leukemia (AML) by comparing cancerous blood stem cells to healthy ones from the same person, with the goal of finding new ways to improve treatment for AML.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $41,614 |
| NIH project number | 1F30CA287962-01A1 |
| Project ID | NIH-10995444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who are willing to provide samples for analysis.
✕Less likely to help
Patients with other types of blood cancers or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
What this research studies
This research investigates how the regulation of gene expression is altered in acute myeloid leukemia (AML) by focusing on a process called alternative polyadenylation. Using advanced techniques like single-cell RNA sequencing, the study aims to compare the gene regulation in cancerous hematopoietic stem cells to that in healthy cells from the same patient. By identifying specific changes in gene regulation, the research seeks to uncover the underlying mechanisms driving AML and potentially improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights into AML that may improve diagnosis and treatment options for patients.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in other cancers, suggesting that this approach may yield valuable insights for AML as well.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Kowalski, Madeline Heidi — New York University School of Medicine
- Study coordinator: Kowalski, Madeline Heidi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.