Understanding how gene regulation affects the development of brain cells involved in epilepsy.
The cis-regulatory grammar and epigenetic control of human interneuron progenitor specification
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10849889
This study is looking at how certain genes work when the brain is developing, especially in the nerve cells that help keep things calm, and it hopes to find out how problems in this process might lead to conditions like epilepsy, which could help us discover new ways to treat these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10849889 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control gene expression during the development of inhibitory neurons in the human brain, particularly focusing on how disruptions in these processes may lead to neurodevelopmental disorders like epilepsy. By using a model that simulates the differentiation of these neurons, the study aims to identify the specific regulatory elements and transcription factors involved in this process. The findings could provide insights into the genetic variations linked to diseases that affect brain function, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a diagnosis of epilepsy or related neurodevelopmental disorders, particularly those with a genetic component.
Not a fit: Patients with neurodevelopmental disorders not linked to genetic variations or those without epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with epilepsy and other neurodevelopmental disorders.
How similar studies have performed: Other research has shown success in understanding gene regulation in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KROLL, KRISTEN L — WASHINGTON UNIVERSITY
- Study coordinator: KROLL, KRISTEN L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disorder