Understanding how gene regulation affects stem cell function in reproduction
Official title: Post-transcriptional regulation of stem and progenitor cell function
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11018682 · Data updated 2026-11-12
This study is looking at how certain proteins help sperm-producing cells grow and change, using mice to learn more about how these processes work, which could help us understand fertility and reproductive health better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 20, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $380,546 |
| NIH project number | 1R35GM156830-01 |
| Project ID | NIH-11018682 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals facing fertility challenges or those interested in understanding reproductive health, particularly related to sperm production.
✕Less likely to help
Patients who are not affected by fertility issues or those outside the reproductive age range may not benefit from this research.
What this research studies
This research investigates the role of post-transcriptional regulation in the function of spermatogonial stem and progenitor cells, which are crucial for sperm production. By using mouse models, the study aims to uncover how specific proteins influence gene expression during the transition from stem cells to differentiated sperm cells. The researchers will employ advanced single-cell techniques to gain insights into these processes, particularly focusing on the effects of retinoic acid signaling on cell differentiation. This work could provide a deeper understanding of fertility and reproductive health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing fertility issues and improving reproductive health.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in stem cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Mikedis, Maria — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Mikedis, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.