Understanding how gene regulation affects stem cell development
Epigenetic gene regulation for stem cell fates
['FUNDING_OTHER'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-11091071
This study is looking at how certain changes in our genes affect stem cells, which are special cells that can turn into different types of cells in the body, and it aims to help us understand how these changes might lead to better treatments for developmental disorders and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11091071 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between gene regulation and stem cell fate, focusing on how epigenetic modifiers influence processes like self-renewal, differentiation, and cell death. By examining the role of specific histone modifications, particularly H3K27, the study aims to uncover the mechanisms that guide stem cell behavior during embryonic development. The research employs advanced techniques to analyze how these modifications respond to various internal and external signals, which could lead to significant insights into developmental disorders and cancers. Patients may benefit from a deeper understanding of these processes, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with pediatric or adult cancers, particularly those associated with dysregulation of stem cell processes.
Not a fit: Patients with conditions unrelated to stem cell regulation or those outside the age range of 21 years and older may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treating developmental disorders and certain cancers by targeting the underlying mechanisms of stem cell regulation.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in stem cells, indicating that this approach could yield valuable insights.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENG, JAMY C. — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: PENG, JAMY C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.