Understanding how gene regulation affects stem cell development
Official title: Epigenetic gene regulation for stem cell fates
Funded at St. Jude Children's Research Hospital · NIH-11091071 · Data updated 2026-11-12
This study is looking at how certain changes in our genes affect stem cells, which are special cells that can turn into different types of cells in the body, and it aims to help us understand how these changes might lead to better treatments for developmental disorders and cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | June 5, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $508,750 |
| NIH project number | 1R35GM158393-01 |
| Project ID | NIH-11091071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with pediatric or adult cancers, particularly those associated with dysregulation of stem cell processes.
✕Less likely to help
Patients with conditions unrelated to stem cell regulation or those outside the age range of 21 years and older may not benefit from this research.
What this research studies
This research investigates the complex interactions between gene regulation and stem cell fate, focusing on how epigenetic modifiers influence processes like self-renewal, differentiation, and cell death. By examining the role of specific histone modifications, particularly H3K27, the study aims to uncover the mechanisms that guide stem cell behavior during embryonic development. The research employs advanced techniques to analyze how these modifications respond to various internal and external signals, which could lead to significant insights into developmental disorders and cancers. Patients may benefit from a deeper understanding of these processes, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in treating developmental disorders and certain cancers by targeting the underlying mechanisms of stem cell regulation.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in stem cells, indicating that this approach could yield valuable insights.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Peng, Jamy C. — St. Jude Children's Research Hospital
- Study coordinator: Peng, Jamy C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.