Understanding how gene regulation affects sperm and egg development
Epigenetic gene regulations in the germline
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11036134
This study looks at how sperm and egg cells develop and how certain biological changes affect this process, with the hope of finding new ways to help people with reproductive issues or genetic conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11036134 on ClinicalTrials.gov |
What this research studies
This research investigates the complex processes of sperm and egg development, focusing on how epigenetic mechanisms influence these processes. By examining the differences between male and female germline development, the study aims to uncover the underlying biological principles that govern the formation of functional sperm and eggs. The research employs advanced techniques such as ATAC sequencing to analyze changes in gene expression and epigenomic reprogramming during germ cell development. Patients may benefit from insights gained that could lead to new treatments for genetic and epigenetic diseases related to reproduction.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with known genetic or epigenetic disorders related to reproductive health.
Not a fit: Patients with conditions unrelated to germline development or those not affected by genetic or epigenetic disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for genetic and epigenetic disorders affecting fertility and development.
How similar studies have performed: Other research has shown success in understanding epigenetic mechanisms in germline development, indicating that this approach has potential for significant findings.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAMEKAWA, SATOSHI — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: NAMEKAWA, SATOSHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.