Understanding how gene regulation affects skin cell development
Epidermal Gene Regulation by Transcription Elongation and Termination
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-10909107
This study is looking at how skin cells control the way genes are turned on and off, which could help us understand and treat skin conditions better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10909107 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control gene expression in skin cells, particularly focusing on the processes of transcription elongation and termination. By studying how these processes differ between undifferentiated and differentiated skin cells, the research aims to uncover the regulatory roles that influence skin health and disease. Utilizing advanced techniques like genomics and proteomics, the team will analyze how specific proteins interact to regulate gene expression in epidermal tissues. This knowledge could lead to better understanding and treatment of skin diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with skin conditions related to gene expression dysregulation, such as basal cell carcinoma.
Not a fit: Patients with skin conditions not related to gene regulation or those without any skin diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating skin diseases by targeting gene regulation mechanisms.
How similar studies have performed: While the specific focus on transcription elongation and termination in epidermal cells is relatively novel, similar approaches in gene regulation have shown promise in other areas of cancer research.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAO, XIAOMIN — NORTHWESTERN UNIVERSITY
- Study coordinator: BAO, XIAOMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Candidate Disease Gene