Understanding how gene regulation affects insulin-producing cells in the pancreas
A novel link between gene regulation and histone modifications governing islet beta-cell development and function
['FUNDING_R01'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11318696
This study is looking at how certain genes help insulin-producing cells in the pancreas work better, which could lead to new treatments for diabetes that affects many people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11318696 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific gene regulators in the development and function of insulin-secreting beta-cells in the pancreas, which are crucial for maintaining blood sugar levels. By studying the interactions of a transcription factor called Islet-1 and its associated proteins, the research aims to uncover new mechanisms that could improve the survival and function of these cells. The approach includes advanced techniques such as mass spectrometry and in vitro assays to identify how these regulators influence gene expression in beta-cells. This knowledge could lead to better therapies for diabetes, a condition affecting millions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 or type 2 diabetes, particularly those experiencing challenges with insulin regulation.
Not a fit: Patients without diabetes or those whose diabetes is well-managed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the function of insulin-producing cells, improving blood sugar control for diabetes patients.
How similar studies have performed: Other research has shown promise in understanding gene regulation in diabetes, but this specific approach focusing on Islet-1 and its interactors is relatively novel.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUNTER, CHAD S — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: HUNTER, CHAD S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus