Understanding how gene regulation affects human disease and evolution
The Evolution of Gene Regulation and Human Disease
This study is looking at how tiny differences in our DNA can affect how our genes work and influence our health, helping us understand why some people get certain diseases and how humans have evolved over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11075835 on NIH RePORTER |
What this research studies
This research investigates how differences in DNA sequences among individuals influence gene regulation and, consequently, disease risk and human evolution. By utilizing advanced machine learning techniques and large-scale functional genomics data, the team aims to model the complex interactions between genetic variants and their effects on health. The research also incorporates ancient DNA to enhance understanding of genetic variation and its implications for modern humans. This comprehensive approach seeks to unravel the challenges of interpreting individual genomes and their contributions to disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of genetic diseases or those interested in understanding their genetic predispositions.
Not a fit: Patients with no genetic predisposition to diseases or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors influencing disease risk, potentially guiding personalized medicine approaches.
How similar studies have performed: Previous research using similar methodologies has shown success in understanding gene regulation and its impact on health, indicating a promising avenue for further exploration.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Capra, John Anthony — University of California, San Francisco
- Study coordinator: Capra, John Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.