Understanding how gene regulation affects gum disease inflammation
Epigenetic Regulation of Periodontal Inflammation
This study is looking at how certain changes in our genes can affect gum inflammation caused by bacteria, and it aims to find new treatments that help reduce this inflammation and heal gums for people with gum disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10761697 on NIH RePORTER |
What this research studies
This research investigates the role of epigenetic regulation, specifically histone acetylation, in the inflammation associated with periodontal disease. It aims to understand how the body's immune response to harmful bacteria contributes to gum disease and explores new therapies that target this inflammation. By using BET inhibitors, which are drugs that can modify gene expression, the research seeks to improve treatment outcomes for patients suffering from periodontitis. The study will analyze how these drugs can suppress inflammation and promote healing in the gums.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with periodontitis or those experiencing significant gum inflammation.
Not a fit: Patients without periodontal disease or those who do not respond to standard treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for periodontal disease, improving oral health and potentially reducing the risk of related systemic conditions.
How similar studies have performed: Other research has shown promise in using epigenetic approaches to treat inflammatory diseases, indicating potential for success in this area as well.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Lin, Zhao — Virginia Commonwealth University
- Study coordinator: Lin, Zhao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.