Understanding how gene regulation affects cancer and cell development
Epigenetic regulation of transcriptional programming
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11132812
This study is looking at how certain proteins help control the way genes work in different types of cells, which is important for understanding cancer and why some treatments stop working, and it’s for anyone interested in how we can improve cancer care.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11132812 on ClinicalTrials.gov |
What this research studies
This research investigates how specific proteins regulate gene expression in different cell types, which is crucial for understanding cancer development and drug resistance. The approach involves studying the interactions between transcription factors and chromatin regulators in both fruit flies and mammalian cells. By examining these interactions, researchers aim to uncover the mechanisms that control cell growth and proliferation, particularly in cancerous cells. The findings could lead to new insights into how to combat drug resistance in cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that exhibit acquired drug resistance.
Not a fit: Patients with non-cancerous conditions or those not affected by drug resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating cancer and overcoming drug resistance.
How similar studies have performed: Previous research has shown success in understanding gene regulation mechanisms, indicating that this approach has potential for significant findings.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KURODA, MITZI I — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: KURODA, MITZI I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause, cancer cell, Cancer Etiology, cancer metastasis, Cancers