Understanding how gene regulation affects cancer and cell development
Official title: Epigenetic regulation of transcriptional programming
Funded at Brigham and Women's Hospital · NIH-11132812 · Data updated 2026-11-12
This study is looking at how certain proteins help control the way genes work in different types of cells, which is important for understanding cancer and why some treatments stop working, and it’s for anyone interested in how we can improve cancer care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $680,200 |
| NIH project number | 5R35GM152063-02 |
| Project ID | NIH-11132812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cancers that exhibit acquired drug resistance.
✕Less likely to help
Patients with non-cancerous conditions or those not affected by drug resistance may not benefit from this research.
What this research studies
This research investigates how specific proteins regulate gene expression in different cell types, which is crucial for understanding cancer development and drug resistance. The approach involves studying the interactions between transcription factors and chromatin regulators in both fruit flies and mammalian cells. By examining these interactions, researchers aim to uncover the mechanisms that control cell growth and proliferation, particularly in cancerous cells. The findings could lead to new insights into how to combat drug resistance in cancer treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating cancer and overcoming drug resistance.
How similar studies have gone: Previous research has shown success in understanding gene regulation mechanisms, indicating that this approach has potential for significant findings.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Kuroda, Mitzi I — Brigham and Women's Hospital
- Study coordinator: Kuroda, Mitzi I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.