Understanding how gene regulation affects brain development in autism
MECHANISMS OF EPIGENETIC REGULATION IN NERVOUS SYSTEM DEVELOPMENT
This study is looking at how changes in DNA can affect brain development and function in children with autism and similar conditions, with the goal of finding new ways to help improve their lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10991711 on NIH RePORTER |
What this research studies
This research investigates the molecular pathways associated with autism spectrum disorder (ASD) and related neurodevelopmental disorders by focusing on the role of DNA methylation in the nervous system. It aims to understand how disruptions in specific genes can alter brain function and contribute to these disorders. The study examines both traditional and unique forms of DNA methylation, particularly in neurons, to uncover how these modifications regulate gene expression and neuronal development. By analyzing the effects of mutations in key genes, the research seeks to identify potential therapeutic targets for improving outcomes in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with autism spectrum disorder or related neurodevelopmental disorders.
Not a fit: Patients who are older than 11 years or do not have a diagnosis of autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for autism spectrum disorder, potentially improving developmental outcomes for affected children.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic mechanisms in neurodevelopmental disorders, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gabel, Harrison W — Washington University
- Study coordinator: Gabel, Harrison W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.