Understanding how gene regulation affects asthma inflammation
Official title: Molecular mechanisms of posttranscriptional gene regulation in asthmatic airway inflammation
Funded at Veterans Health Administration · NIH-10928153 · Data updated 2026-11-12
This study is looking at how certain proteins and tiny molecules in our cells affect inflammation in asthma, with the hope of finding new ways to help people who struggle with their asthma, especially those who don't get better with current treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01CX002491-02 |
| Project ID | NIH-10928153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military personnel and veterans suffering from asthma, especially those with steroid-resistant forms of the disease.
✕Less likely to help
Patients with asthma who respond well to existing treatments or do not have significant airway inflammation may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind gene regulation in asthma, particularly focusing on how RNA binding proteins (RBPs) and microRNAs influence inflammation in the airways. By studying the role of a specific RBP called HuR, which is known to affect the stability and translation of mRNA related to inflammation, the research aims to uncover new insights into asthma treatment. The team will use advanced techniques like RNA Immunoprecipitation and genetically modified mouse models to explore how these mechanisms operate in different types of asthma. This could lead to better-targeted therapies for patients suffering from asthma, especially those who do not respond well to current treatments.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for asthma, particularly for patients who currently have limited options.
How similar studies have gone: Previous research has shown promising results in understanding the role of RBPs in inflammation, suggesting that this approach could yield valuable insights into asthma treatment.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Atasoy, Ulus — Veterans Health Administration
- Study coordinator: Atasoy, Ulus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.