Understanding how gene regulation affects asthma inflammation
Molecular mechanisms of posttranscriptional gene regulation in asthmatic airway inflammation
['FUNDING_OTHER'] · VETERANS HEALTH ADMINISTRATION · NIH-10928153
This study is looking at how certain proteins and tiny molecules in our cells affect inflammation in asthma, with the hope of finding new ways to help people who struggle with their asthma, especially those who don't get better with current treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS HEALTH ADMINISTRATION (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10928153 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind gene regulation in asthma, particularly focusing on how RNA binding proteins (RBPs) and microRNAs influence inflammation in the airways. By studying the role of a specific RBP called HuR, which is known to affect the stability and translation of mRNA related to inflammation, the research aims to uncover new insights into asthma treatment. The team will use advanced techniques like RNA Immunoprecipitation and genetically modified mouse models to explore how these mechanisms operate in different types of asthma. This could lead to better-targeted therapies for patients suffering from asthma, especially those who do not respond well to current treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include military personnel and veterans suffering from asthma, especially those with steroid-resistant forms of the disease.
Not a fit: Patients with asthma who respond well to existing treatments or do not have significant airway inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for asthma, particularly for patients who currently have limited options.
How similar studies have performed: Previous research has shown promising results in understanding the role of RBPs in inflammation, suggesting that this approach could yield valuable insights into asthma treatment.
Where this research is happening
ANN ARBOR, UNITED STATES
- VETERANS HEALTH ADMINISTRATION — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ATASOY, ULUS — VETERANS HEALTH ADMINISTRATION
- Study coordinator: ATASOY, ULUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.