Understanding how gene organization affects breast cancer
Epigenetic Control and Genome Organization
This study is looking at how the way our genes are organized and controlled can affect breast cancer growth and behavior, with the hope that the findings will help create better treatments for patients with advanced breast cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11074066 on NIH RePORTER |
What this research studies
This research investigates the relationship between genome organization and epigenetic control of gene expression specifically in breast cancer. By employing a multidisciplinary approach, the team aims to uncover how these factors influence cancer cell growth, hormone responsiveness, and the metastatic behavior of breast cancer cells. The research includes studying the interactions of transcription factors and their role in maintaining gene expression fidelity during cell division, as well as exploring the effects of noncoding RNAs on aggressive breast cancer phenotypes. Patients may benefit from insights that could lead to more effective therapies for advanced breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced or aggressive breast cancer.
Not a fit: Patients with early-stage breast cancer or non-breast cancer conditions may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve treatment outcomes for patients with advanced breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetics and genome organization in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Stein, Gary S. — University of Vermont & St Agric College
- Study coordinator: Stein, Gary S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.