Understanding how gene networks control cell identity during development
Official title: Mechanisms of repressive interactions between developmental gene regulatory networks
Funded at Carnegie-Mellon University · NIH-10917113 · Data updated 2026-11-12
This study looks at how certain genes control the identity of cells as they develop, using sea urchins to understand how some genes can be turned off to help guide cell growth, which could lead to new treatments for patients needing cell therapies.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31GM149185-02 |
| Project ID | NIH-10917113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals interested in regenerative therapies or those with conditions related to developmental disorders.
✕Less likely to help
Patients with acute conditions that do not involve developmental processes may not receive direct benefits from this research.
What this research studies
This research investigates how gene regulatory networks (GRNs) influence the identity of cells during development by both activating and repressing certain genes. By using the sea urchin as a model organism, the study aims to uncover the mechanisms behind these repressive interactions that are crucial for determining cell fate. The approach involves analyzing specific transcription factors and their roles in silencing alternative gene programs, which is essential for both normal development and regenerative medicine. Patients may benefit from insights gained into how cells can be reprogrammed for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to advancements in regenerative medicine by improving our understanding of how to manipulate cell identities for therapeutic applications.
How similar studies have gone: Previous research has shown success in understanding gene regulatory networks, but the specific focus on repressive interactions in this context is relatively novel.
Where this research is happening
-
Carnegie-Mellon University
Pittsburgh, United States Active
Researchers
- Principal investigator: Douglas, William B — Carnegie-Mellon University
- Study coordinator: Douglas, William B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.