Understanding how gene networks affect myeloid cell development in the brain
Official title: Investigating novel gene regulatory networks for development of myeloid cells
Funded at University of Notre Dame · NIH-11001630 · Data updated 2026-11-12
This study is looking at how certain genes affect the development of important brain cells called microglia, which help keep our brains healthy and fight off illness, to better understand their role in conditions like autism and Alzheimer's disease, with the hope of finding new treatments to improve brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | July 9, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $49,974 |
| NIH project number | 1F99NS139552-01 |
| Project ID | NIH-11001630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism or Alzheimer's disease, particularly those under 21 years old.
✕Less likely to help
Patients with conditions unrelated to myeloid cell function or those over 21 years old may not benefit from this research.
What this research studies
This research investigates the genetic networks that regulate the development of myeloid cells, particularly microglia, which are essential for brain health and immune response. By studying these cells, the research aims to uncover how they contribute to conditions like autism and Alzheimer's disease. The approach involves identifying specific genetic markers and understanding their roles in microglia production and function. This could lead to new insights into therapies that target these cells for better brain health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological conditions by targeting the underlying genetic mechanisms of myeloid cell function.
How similar studies have gone: Previous research has shown promise in understanding microglia's role in various neurological conditions, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Hoover, Camden — University of Notre Dame
- Study coordinator: Hoover, Camden
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.