Understanding how gene mutations affect breast cancer risk
Resolving the cancer relevance of predisposition gene mutations
This study is looking at how certain gene changes might raise the chances of getting breast cancer, especially in minority groups, to help doctors give better advice and treatment options for those at risk, particularly if they have a family history of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10917143 on NIH RePORTER |
What this research studies
This research investigates the role of specific gene mutations in increasing the risk of breast cancer, particularly focusing on minority populations. It aims to improve the clinical application of genetic testing results to better manage patient risk and tailor breast cancer therapies. The study will also explore new gene variants that may contribute to breast cancer risk, especially for those with a family history of the disease. By assessing cancer risks based on age and population, the research seeks to provide more accurate risk estimates for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of breast cancer or those who have been identified with specific gene mutations linked to the disease.
Not a fit: Patients without a family history of breast cancer or those not carrying the relevant gene mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective strategies for breast cancer prevention and treatment.
How similar studies have performed: Previous research has shown success in identifying gene mutations related to breast cancer, making this approach a continuation of established findings.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Couch, Fergus Joseph — Mayo Clinic Rochester
- Study coordinator: Couch, Fergus Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.