Understanding how gene instructions are read in health and disease
Regulation and impact of alternative splicing in biology and disease
This work explores how our bodies read genetic instructions, especially when mistakes in this process lead to human diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11113816 on NIH RePORTER |
What this research studies
Our bodies rely on a process called pre-mRNA splicing to correctly read the instructions in our genes. When this process goes wrong, it can cause genetic diseases and contribute to various types of cancer. This project aims to uncover the basic ways that splicing works and how it is controlled, which is key to understanding both normal body functions and human illnesses. We use advanced lab techniques, including cell models and genetic analysis, to study how different parts of our cells interact to ensure genes are read correctly. By understanding these fundamental mechanisms, we hope to find new ways to address diseases caused by splicing errors.
Who could benefit from this research
Good fit: This foundational work does not directly involve patient participation but aims to benefit individuals with genetic diseases or cancer by improving our understanding of their conditions.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this basic understanding could lead to new ways to diagnose or treat human genetic diseases and various cancers by targeting the underlying splicing errors.
How similar studies have performed: Research into pre-mRNA splicing is a well-established field, and this project builds upon existing knowledge while pursuing novel directions in understanding context-dependent splicing regulation.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Hertel, Klemens J — University of California-Irvine
- Study coordinator: Hertel, Klemens J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.