Understanding how gene expression varies in populations and individual cells
Statistical methods for elucidating regulatory mechanisms and functional impacts of transcriptome variation at population and single-cell scales
This study is looking at how genes behave in different people and at the single-cell level to help us understand diseases better, and it’s designed for anyone interested in how gene changes can affect health over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11087527 on NIH RePORTER |
What this research studies
This research focuses on developing advanced statistical methods to analyze gene expression variations at both population and single-cell levels. By utilizing bulk RNA sequencing and single-cell RNA sequencing techniques, the project aims to identify genes associated with diseases and traits, while also addressing challenges in understanding how gene expression changes over time. The researchers will create a unified framework that improves the detection of genetic associations with gene expression, making it applicable to various RNA-seq data types. This work could lead to better insights into the regulatory mechanisms behind gene expression variations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations that may be linked to specific diseases or traits.
Not a fit: Patients without significant genetic variations or those not affected by the conditions being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors influencing diseases, potentially leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: Other research has shown success in using RNA sequencing techniques to uncover gene expression patterns, indicating that this approach is promising and builds on established methodologies.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Li, Jingyi Jessica — University of California Los Angeles
- Study coordinator: Li, Jingyi Jessica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.