Understanding how gene expression varies in healthy and diseased cells
Computational methods for delineating subcellular and cellular spatial transcriptional heterogeneity along developmental trajectories
This study is looking at how healthy and sick cells behave differently at a genetic level, which could help us understand diseases better and find new ways to diagnose and treat them, so patients can get better care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10892223 on NIH RePORTER |
What this research studies
This research focuses on how differences in gene expression between healthy and diseased cells can reveal important biological insights. By using advanced computational methods and next-generation sequencing technologies, the project aims to analyze the spatial localization of mRNAs and their role in protein production. The goal is to quantitatively assess transcriptional differences in individual cells, which could help in understanding disease mechanisms and developing new therapeutic strategies. Patients may benefit from the findings that could lead to improved diagnostics and treatments based on cellular behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve significant cellular and molecular changes, such as cancer or genetic disorders.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for various diseases by revealing how gene expression changes at the cellular level.
How similar studies have performed: Other research has shown success in using computational methods to analyze gene expression, indicating that this approach has potential for significant findings.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Fan, Jean — Johns Hopkins University
- Study coordinator: Fan, Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.