Understanding how gene expression varies between identical cells
Molecular Properties of Transcription Factors that Control Cell-to-Cell Variability in Gene Expression
This study looks at how identical cells can behave differently in the same environment by exploring sudden bursts of gene activity, which might help us understand how cells grow and why some cancers resist treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10789887 on NIH RePORTER |
What this research studies
This research investigates the differences in gene expression among genetically identical cells in the same environment, focusing on the concept of stochastic bursts of transcription. By examining how these bursts contribute to variability in gene expression, the study aims to uncover the molecular mechanisms that allow cells to control variability independently from average expression levels. This could have implications for understanding developmental processes and cancer treatment resistance. The research employs a model that separates the regulation of burst size and frequency to analyze gene expression patterns.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene expression variability, such as certain cancers or developmental disorders.
Not a fit: Patients with stable gene expression profiles or those not affected by variability in gene expression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for targeting cancer cells and enhancing cell reprogramming techniques.
How similar studies have performed: Previous research has shown that understanding gene expression variability can lead to significant advancements in cancer treatment and developmental biology, indicating a promising avenue for this study.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cohen, Barak a — Washington University
- Study coordinator: Cohen, Barak a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.