Understanding how gene expression is regulated by chromatin
Official title: ILLUMINATION OF CHROMATIN REGULATION VIA CHEMICAL CONTROLLED PROXIMITY
Funded at Univ of North Carolina Chapel Hill · NIH-11087572 · Data updated 2026-11-12
This study is exploring how certain proteins help control gene activity in our cells, with the goal of finding new treatments that can stop harmful gene silencing, which could help patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $440,289 |
| NIH project number | 5R35GM148365-03 |
| Project ID | NIH-11087572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or developmental diseases that may be influenced by chromatin regulation.
✕Less likely to help
Patients with conditions unrelated to chromatin regulation or gene expression may not benefit from this research.
What this research studies
This research investigates the mechanisms behind how chromatin regulates gene expression, focusing on specific enzymes involved in this process. By using chemically controlled proximity, the researchers can manipulate these enzymes in real-time, allowing for a deeper understanding of gene repression pathways. The study aims to visualize these processes at the single-cell level and develop new drugs that can inhibit unwanted gene repression. Patients may benefit from advancements in drug discovery related to chromatin regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and developmental disorders by targeting gene regulation mechanisms.
How similar studies have gone: Other research has shown promising results in understanding chromatin regulation, but this approach using chemically controlled proximity is relatively novel.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Hathaway, Nathaniel a. — Univ of North Carolina Chapel Hill
- Study coordinator: Hathaway, Nathaniel a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.