Understanding how gene expression is organized in mitochondria
Official title: Flow Of Gene Expression Across Mitochondrial Condensates
Funded at Pennsylvania State University, the · NIH-10938849 · Data updated 2026-11-12
This study is looking at how tiny parts inside our cells, called mitochondria, work together to form important structures, and it hopes to find out how problems in this process might lead to diseases, which could help develop better treatments for people with mitochondrial issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $387,430 |
| NIH project number | 1R35GM154931-01 |
| Project ID | NIH-10938849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction or genetic disorders affecting mitochondrial gene expression.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or gene regulation may not benefit from this research.
What this research studies
This research investigates the organization of gene expression within mitochondria, focusing on how biomolecules self-organize into functional structures called mitochondrial condensates. By using advanced microscopy techniques and theoretical modeling, the study aims to uncover the interactions that lead to the formation of these structures and how disruptions in this process can lead to mitochondrial dysfunction. Patients may benefit from insights gained into the fundamental mechanisms of gene regulation that could inform future treatments for mitochondrial-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to mitochondrial dysfunction.
How similar studies have gone: Other research has shown promise in understanding gene regulation through similar approaches, indicating potential for significant advancements in this area.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Feric, Marina — Pennsylvania State University, the
- Study coordinator: Feric, Marina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.