Understanding how gene expression is coordinated in cellular pathways
Official title: Coordination of gene expression and molecular function in known pathways
Funded at California Institute of Technology · NIH-10998595 · Data updated 2026-11-12
This study is looking at how our cells control the activity of genes when faced with different situations, using advanced techniques to see how certain genes work together, which could help us better understand how cells respond to changes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project start | February 15, 2025 |
| Project end | February 14, 2028 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F30GM156092-01 |
| Project ID | NIH-10998595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve significant cellular regulation and gene expression changes.
✕Less likely to help
Patients with stable conditions that do not involve cellular or genetic variability may not benefit from this research.
What this research studies
This research investigates how cells regulate gene expression in response to different conditions by analyzing the activity levels of biological pathways. By utilizing human single-cell RNA sequencing data and established pathway models, the project aims to identify patterns of gene expression that are coordinated within these pathways. This approach seeks to determine whether specific genes consistently change together when pathways are activated or inhibited, providing insights into cellular physiology and function. The findings could help clarify which genes are critical for understanding pathway regulation and cellular responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cellular functions and better strategies for targeting diseases at the molecular level.
How similar studies have gone: Other research has shown promising results in understanding gene expression patterns and their implications for cellular functions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
California Institute of Technology
Pasadena, United States Active
Researchers
- Principal investigator: Markarian, Nicholas — California Institute of Technology
- Study coordinator: Markarian, Nicholas
Related research
Other NIH-funded projects on the same topics.
-
Genetic and Neural Drivers of Sleep in Zebrafish
Researchers are studying how genes and brain signals control sleep using zebrafish to understand why sleep disorders happen and how to treat them.
-
Wireless, skin-friendly neck wearable to support voice/airway care
A neck-worn, wireless sensor system combines two measurements to help people with voice and airway problems manage symptoms and stay adherent to treatment.
-
Bacterial gene activity in human tissues to link microbes and host health
A research project to map which genes are active in both human tissues and their resident bacteria to better understand conditions like Crohn’s disease.
-
In Situ Amplification for Biological Imaging using Hybridization Chain Reaction
A research grant supporting a new imaging approach that helps scientists visualize where RNA and proteins are located inside tissues and embryos.
-
WormBase: a life science data hub for C. elegans and other nematodes
Aimed at continuously improving WormBase, a key online data resource used by researchers studying C. elegans and related nematodes, to help scientists access genome and gene information more efficiently.
-
Alliance Central: A platform to build smarter genome knowledge bases
A NIH-funded project to create a next-generation software platform and data framework that helps scientists integrate and harmonize genome and model-organism data to better understand human health and disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.