Understanding how gene expression is coordinated in cellular pathways
Coordination of gene expression and molecular function in known pathways
['FUNDING_FELLOWSHIP'] · CALIFORNIA INSTITUTE OF TECHNOLOGY · NIH-10998595
This study is looking at how our cells control the activity of genes when faced with different situations, using advanced techniques to see how certain genes work together, which could help us better understand how cells respond to changes.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CALIFORNIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (PASADENA, UNITED STATES) |
| Trial ID | NIH-10998595 on ClinicalTrials.gov |
What this research studies
This research investigates how cells regulate gene expression in response to different conditions by analyzing the activity levels of biological pathways. By utilizing human single-cell RNA sequencing data and established pathway models, the project aims to identify patterns of gene expression that are coordinated within these pathways. This approach seeks to determine whether specific genes consistently change together when pathways are activated or inhibited, providing insights into cellular physiology and function. The findings could help clarify which genes are critical for understanding pathway regulation and cellular responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve significant cellular regulation and gene expression changes.
Not a fit: Patients with stable conditions that do not involve cellular or genetic variability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cellular functions and better strategies for targeting diseases at the molecular level.
How similar studies have performed: Other research has shown promising results in understanding gene expression patterns and their implications for cellular functions, suggesting that this approach could yield valuable insights.
Where this research is happening
PASADENA, UNITED STATES
- CALIFORNIA INSTITUTE OF TECHNOLOGY — PASADENA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARKARIAN, NICHOLAS — CALIFORNIA INSTITUTE OF TECHNOLOGY
- Study coordinator: MARKARIAN, NICHOLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.