Understanding how gene expression is controlled in cells
Dissecting the Dynamic Interplay Between, p53, Chromatin and Transcriptional Bursting in Single Cells
This study is exploring how genes in our cells turn on and off, especially in relation to cancer, to help us understand what goes wrong in diseases and how it might lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10892848 on NIH RePORTER |
What this research studies
This research investigates the complex processes that regulate gene expression in mammalian cells, focusing on how genes can switch between active and inactive states. By using advanced live cell imaging techniques, the study aims to uncover the molecular mechanisms behind transcriptional bursting and transcriptional memory, which are crucial for understanding gene behavior in health and disease. The research specifically looks at the role of chromatin and transcription factors in these processes, particularly in the context of cancer. Patients may benefit from insights gained about how gene expression goes awry in diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or genetic conditions related to dysregulated gene expression.
Not a fit: Patients with conditions unrelated to gene expression or those not diagnosed with cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting gene expression in cancer treatment.
How similar studies have performed: Other research has shown promising results in understanding gene expression dynamics, making this approach both relevant and potentially impactful.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Coleman, Robert — Albert Einstein College of Medicine
- Study coordinator: Coleman, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.