Understanding how gene expression in the habenula affects opioid addiction and depression
Regulation of Gene Expression in the Human Habenula in Comorbid Opioid Addiction and Depression
['FUNDING_R01'] · LIEBER INSTITUTE, INC. · NIH-11105994
This study is looking at how certain genes in a part of the brain called the habenula, which helps control our mood and motivation, might be linked to opioid addiction and depression, with the goal of finding better ways to treat these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LIEBER INSTITUTE, INC. (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11105994 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between gene expression in the habenula, a brain region involved in motivation and mood regulation, and its role in opioid addiction and depression. By utilizing advanced technologies, the study aims to create detailed molecular maps of the habenula to identify specific cell types and their functions. This approach will help uncover the genetic and epigenetic factors that contribute to the dysfunction of this brain area in individuals suffering from both conditions. The findings could lead to new insights into how these disorders are interconnected and how they can be treated more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing both opioid addiction and major depressive disorder.
Not a fit: Patients who do not have a comorbidity of opioid addiction and depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients dealing with both opioid addiction and depression.
How similar studies have performed: Other research has shown promising results in understanding the neurobiological underpinnings of addiction and depression, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- LIEBER INSTITUTE, INC. — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAYNARD, KRISTEN ROSE — LIEBER INSTITUTE, INC.
- Study coordinator: MAYNARD, KRISTEN ROSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder