Understanding how gene expression changes with aging and affects health
Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity
This study is looking at how aging and lung infections, like the flu, affect the way our genes work, especially in older adults, to help find new ways to improve health as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11026398 on NIH RePORTER |
What this research studies
This research investigates how the balance of gene expression changes as people age, particularly focusing on the effects of aging and lung infections like influenza A. By analyzing data from various models, the study aims to uncover how imbalances in short and long gene transcripts can lead to health issues in older adults. The approach includes innovative laboratory techniques and machine learning to explore these complex biological processes. Patients may benefit from insights that could lead to new treatments or interventions for age-related health declines.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who are experiencing age-related health issues.
Not a fit: Patients under 21 years old or those without age-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving health and resilience in older adults.
How similar studies have performed: Other research has shown promising results in understanding gene expression and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Stoeger, Thomas — Northwestern University
- Study coordinator: Stoeger, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.