Understanding how gene differences affect immune cells in people
Linking genome variation to transcriptional network dynamics in human B cells
This project looks at how tiny differences in our genes affect the immune cells called B cells, which play a role in autoimmune diseases.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11118852 on NIH RePORTER |
What this research studies
Our immune system's B cells are crucial for fighting infections and are also involved in autoimmune diseases. This project aims to create a detailed map of how genes control these B cells, both when they are resting and when they are active. We are using advanced genetic tools to understand how small changes in a person's DNA can affect how their B cells behave. By understanding these complex genetic networks, we hope to learn more about why autoimmune diseases develop and how B cells respond to vaccines.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals with autoimmune diseases in the future.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: This work could lead to a better understanding of autoimmune diseases and vaccine responses, potentially paving the way for new treatments or improved disease management.
How similar studies have performed: Similar genomic mapping approaches have shown success in understanding immune cells in animal models, providing a strong foundation for this human-focused work.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Singh, Harinder — University of Pittsburgh at Pittsburgh
- Study coordinator: Singh, Harinder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.