Understanding how gene changes in the brain affect appetite and body weight
Alternative polyadenylation as a genetic regulatory mechanism to bridge genome to phenome in the nervous system
This research explores how genetic changes in the brain's appetite control centers might contribute to conditions like anorexia nervosa and obesity.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11093554 on NIH RePORTER |
What this research studies
Many people struggle with appetite disorders, from severe anorexia nervosa to obesity, both of which are serious health concerns. This project looks into how the brain's appetite control system might be reprogrammed at a genetic level, leading to these conditions. We are focusing on a process called alternative polyadenylation, which helps regulate how genes are expressed. By understanding these genetic changes, we hope to uncover new ways to address dysfunctional eating behaviors.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on the biological mechanisms relevant to individuals with anorexia nervosa, obesity, or other appetite disorders.
Not a fit: Patients not experiencing appetite disorders or related metabolic conditions would not directly benefit from this specific line of research.
Why it matters
Potential benefit: Success in this work could lead to a deeper understanding of the genetic roots of appetite disorders, potentially paving the way for new treatments for anorexia nervosa and obesity.
How similar studies have performed: The principal investigator's own published work has shown a connection between appetite changes and alternative polyadenylation in the hypothalamus, suggesting a promising direction for this novel approach.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Brutman, Julianna Nicole — University of Washington
- Study coordinator: Brutman, Julianna Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.