Understanding how gene activity is regulated by chromatin changes
Methods to Elucidate the Dynamics of Transcriptional Regulation and Chromatin
This study looks at how the way our genes are packed in cells affects how they work, especially when cells face different challenges, and it aims to help us understand how cells adapt to stress and changes in their environment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11093364 on NIH RePORTER |
What this research studies
This research investigates the dynamic relationship between chromatin structure and gene transcription within cells. By analyzing how these two elements influence each other in response to various internal and external conditions, the research aims to develop predictive models of gene activity. The approach involves profiling chromatin and transcription states simultaneously in model organisms like budding yeast, allowing for a comprehensive understanding of cellular responses. This could lead to insights into how cells adapt to stress and other environmental changes.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with cancers or other conditions related to gene regulation and cellular function.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular adaptation or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and other diseases by targeting the mechanisms of gene regulation.
How similar studies have performed: Other research has shown success in understanding gene regulation through chromatin dynamics, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Hartemink, Alexander J — Duke University
- Study coordinator: Hartemink, Alexander J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.