Understanding how gene activity is controlled in living cells during development
Control of the 4D chromatin landscape underlying gene activity during development
['FUNDING_U01'] · PRINCETON UNIVERSITY · NIH-10901843
This study is exploring how genes work inside living cells and tissues, using new imaging tools to see and change how genes are turned on and off, which could help us understand how cells develop and what goes wrong in diseases like cancer.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-10901843 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control gene activity in real-time within living cells and tissues. By developing innovative imaging techniques and optogenetic tools, the study aims to measure and manipulate the interactions between chromosomes and transcription factors. This approach will help to clarify how gene expression is regulated during cellular differentiation and how disruptions in these processes can lead to diseases such as cancer. The research focuses on achieving unprecedented resolution in understanding these complex biological interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers that may be linked to disruptions in gene expression.
Not a fit: Patients with conditions unrelated to gene regulation or chromosomal interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for developmental disorders and cancers.
How similar studies have performed: While the approach is innovative, similar studies have shown promise in understanding gene regulation, suggesting potential for success.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREGOR, THOMAS — PRINCETON UNIVERSITY
- Study coordinator: GREGOR, THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.