Understanding how gastric intestinal changes lead to cancer
Mechanisms underlying gastric intestinal metaplasia and carcinogenesis
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10906853
This study is looking into how things like bile reflux, smoking, and H. pylori infection can lead to a condition called gastric intestinal metaplasia, which might turn into stomach cancer, and it aims to find out how certain genes are involved to help improve prevention and treatment options for people at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10906853 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that lead to gastric intestinal metaplasia, a condition that can progress to gastric cancer. It focuses on understanding how certain factors, such as bile reflux, smoking, and H. pylori infection, contribute to this condition. The study aims to identify common molecular pathways involved in the development of intestinal metaplasia in different parts of the stomach. By examining the role of specific genes and transcription factors, the research seeks to uncover fundamental insights that could inform prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for gastric cancer, such as non-Hispanic Blacks, Hispanics, and non-Hispanic Asian or Pacific Islanders.
Not a fit: Patients who do not have risk factors for gastric cancer or intestinal metaplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for gastric cancer, particularly for high-risk populations.
How similar studies have performed: Previous research has shown success in understanding similar mechanisms in other cancers, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUSTGI, ANIL K — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: RUSTGI, ANIL K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: American Cancer Society, Barrett Syndrome