Understanding how gastric bypass surgery affects metabolism and diabetes management
Role of intestinal luminal and epigenetic factors to mediate intestinal metabolic remodeling after gastric bypass surgery
This study is looking at how Roux-en-Y gastric bypass surgery helps people with type 2 diabetes by changing the way their intestines work, and it hopes to find new ways to achieve similar benefits without needing surgery.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10597070 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the effectiveness of Roux-en-Y gastric bypass surgery in treating type 2 diabetes. It focuses on how changes in the intestine after surgery can influence energy metabolism and potentially lead to diabetes remission. The study will analyze epigenetic changes in intestinal tissues and how these changes are affected by nutrients in the gut. By using advanced techniques like RNA sequencing and organoid models, the research aims to uncover new therapeutic strategies that could mimic the benefits of surgery without the need for invasive procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who are considering or have undergone gastric bypass surgery.
Not a fit: Patients who do not have type 2 diabetes or those who are not candidates for gastric bypass surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, less invasive treatments for type 2 diabetes that replicate the metabolic benefits of gastric bypass surgery.
How similar studies have performed: Previous research has shown promising results in understanding metabolic changes after gastric bypass, indicating that this approach has potential for significant advancements.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Stefater-Richards, Margaret — Boston Children's Hospital
- Study coordinator: Stefater-Richards, Margaret
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.