Understanding how gabapentin works for children with nerve pain
Precision Medicine in Pediatric Rehabilitation - Variability in Gabapentin Exposure
This study is looking at how different kids respond to gabapentin, a medicine for nerve pain, to find the best way to give it to each child based on their unique needs, helping them manage their pain better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10676082 on NIH RePORTER |
What this research studies
This research investigates the variability in how children respond to gabapentin, a medication commonly used to treat nerve pain. By examining factors that affect how much of the drug reaches the brain and its effectiveness, the study aims to develop a personalized dosing strategy for pediatric patients. The research will utilize genetic and biological data to better understand the transport mechanisms of gabapentin across the blood-brain barrier. Ultimately, this work seeks to improve pain management for children with disabilities by tailoring treatments to individual needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients experiencing neuropathic pain who are prescribed gabapentin.
Not a fit: Patients who do not have neuropathic pain or are not prescribed gabapentin may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies for children, reducing their suffering and improving their quality of life.
How similar studies have performed: Previous studies have shown promise in understanding drug transport mechanisms across the blood-brain barrier, suggesting that this approach could yield valuable insights.
Where this research is happening
Kansas City, United States
- Children's Mercy Hosp (Kansas City, Mo) — Kansas City, United States (Active)
Researchers
- Principal investigator: Mclaughlin, Matthew — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Mclaughlin, Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.