Understanding how GABAergic interneurons develop in the brain and their link to autism.
GABAergic Interneuron Dysfunction in Developing Cortical Circuits Underlying Autism Spectrum Disorders
This study is looking at how certain brain cells, important for controlling brain activity, develop and how things in our environment might affect them, which could help us understand more about autism and childhood epilepsy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10975040 on NIH RePORTER |
What this research studies
This research investigates the role of GABAergic interneurons in the cerebral cortex, which are crucial for brain inhibition and are linked to autism and childhood epilepsy. The study aims to uncover how environmental factors influence the development of these neurons and how disruptions in their maturation can lead to long-term brain dysfunction. Using a mouse model, researchers will explore specific interneuron subtypes and the signaling pathways involved in their development, focusing on calcium-dependent mechanisms. This work could provide insights into the biological underpinnings of autism spectrum disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with autism spectrum disorders who may benefit from a deeper understanding of the biological mechanisms involved.
Not a fit: Patients without autism spectrum disorders or those who are not adults may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for autism spectrum disorders by targeting the underlying neuronal dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding GABAergic dysfunction in relation to autism, indicating that this approach has potential for significant findings.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: De Marco Garcia, Natalia Vanesa — Weill Medical Coll of Cornell Univ
- Study coordinator: De Marco Garcia, Natalia Vanesa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.