Understanding how Gα13 helps prevent pancreatic cancer
Official title: Elucidating the mechanism of Ga13 mediated tumor suppression in pancreatic cancer
Funded at State University New York Stony Brook · NIH-11175147 · Data updated 2026-11-12
This study is looking at how a protein called Gα13 affects pancreatic cancer growth and survival, using mice to understand how its absence might change tumor development and inflammation, with the hope of finding new ways to help treat pancreatic cancer patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $405,234 |
| NIH project number | 7R01CA283925-02 |
| Project ID | NIH-11175147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic cancer or those at high risk for developing this disease.
✕Less likely to help
Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
What this research studies
This research investigates the role of a protein called Gα13 in pancreatic cancer, focusing on how its absence affects tumor growth and survival. The study uses a genetic mouse model to explore the mechanisms behind tumor development, particularly looking at the relationship between Gα13, inflammation, and a signaling pathway known as mTOR. By examining these interactions, the research aims to uncover potential therapeutic targets that could improve treatment outcomes for pancreatic cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating pancreatic cancer by targeting the pathways influenced by Gα13.
How similar studies have gone: Previous research has shown that targeting mTOR signaling can be effective in treating certain cancers, suggesting that this approach may hold promise.
Where this research is happening
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State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Shields, Mario — State University New York Stony Brook
- Study coordinator: Shields, Mario
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.