Understanding how G proteins affect the development of cilia in neurons related to neurodevelopmental disorders
Official title: Function and regulation of heterotrimeric G proteins in ciliogenesis and pathobiology of neurodevelopmental disorders
Funded at Worcester Polytechnic Institute · NIH-10651317 · Data updated 2026-11-12
This study is looking at how a special protein called RIC-8 helps shape tiny hair-like structures called cilia in nerve cells, which are important for brain development, and it could help us understand more about conditions that affect how the brain grows and works.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Worcester Polytechnic Institute NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | April 5, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $363,984 |
| NIH project number | 1R15HD109706-01A1 |
| Project ID | NIH-10651317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurodevelopmental disorders who may benefit from advancements in understanding their condition.
✕Less likely to help
Patients with neurodevelopmental disorders unrelated to cilia dysfunction may not receive direct benefits from this research.
What this research studies
This research investigates the role of heterotrimeric G proteins in the formation and function of cilia, which are crucial for neuron development. The study aims to uncover how a specific protein, RIC-8, influences cilia morphology and signaling in sensory neurons. By using advanced techniques such as genome editing and in vivo imaging, researchers will explore the molecular mechanisms behind these processes. This work could lead to a better understanding of neurodevelopmental disorders and their underlying causes.
Why it matters
Potential benefit: If successful, this research could provide insights into new therapeutic targets for treating neurodevelopmental disorders.
How similar studies have gone: While the specific approach of investigating RIC-8 in cilia development is innovative, similar studies have shown that understanding G protein signaling can lead to breakthroughs in treating neurodevelopmental disorders.
Where this research is happening
-
Worcester Polytechnic Institute
Worcester, United States Active
Researchers
- Principal investigator: Nechipurenko, Inna — Worcester Polytechnic Institute
- Study coordinator: Nechipurenko, Inna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.