Understanding how G protein signaling works in the body
Official title: Structural dynamics and energy landscapes of G protein signaling
Funded at California State University Northridge · NIH-11087561 · Data updated 2026-11-12
This study is looking at how certain proteins in our body, called G protein-coupled receptors, work and interact with different substances, which could help us understand and improve treatments for various health issues like heart problems, immune disorders, and more.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State University Northridge NIH-funded |
| Lab location | 1 site (Northridge, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $147,500 |
| NIH project number | 5R16GM153621-02 |
| Project ID | NIH-11087561 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions influenced by GPCR signaling, such as metabolic disorders, cardiovascular diseases, or neurological conditions.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling may not receive any benefit from this research.
What this research studies
This research investigates the structural dynamics and energy landscapes of G protein-coupled receptors (GPCRs), which play a crucial role in transmitting signals from hormones and neurotransmitters to cells. By examining how these receptors interact with various ligands and G proteins, the research aims to uncover the complex signaling mechanisms that regulate numerous physiological processes. Patients may benefit from insights gained about GPCRs, as these receptors are key therapeutic targets for a wide range of diseases affecting the metabolic, nervous, cardiovascular, and immune systems.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting GPCRs, improving treatment options for various diseases.
How similar studies have gone: Previous research has shown that targeting GPCRs can lead to significant advancements in treatment, indicating a promising avenue for further exploration.
Where this research is happening
-
California State University Northridge
Northridge, United States Active
Researchers
- Principal investigator: Abrol, Ravinder — California State University Northridge
- Study coordinator: Abrol, Ravinder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.