Understanding how G protein signaling works in the body
Official title: Addressing the complexity and plasticity of heterotrimeric G protein signaling
Funded at Boston University Medical Campus · NIH-11012011 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells help them communicate and work together, with the hope of finding new ways to treat diseases that affect many people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $694,875 |
| NIH project number | 1R35GM156286-01 |
| Project ID | NIH-11012011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that are influenced by G protein signaling, such as metabolic disorders, neurological diseases, or immune system dysfunctions.
✕Less likely to help
Patients with conditions unrelated to G protein signaling or those who do not respond to GPCR-targeted therapies may not benefit from this research.
What this research studies
This research investigates the complex mechanisms of G protein-coupled receptors (GPCRs) and heterotrimeric G proteins, which play a crucial role in cellular communication and are involved in various physiological processes. By exploring the flexibility and adaptability of these signaling pathways, the research aims to uncover new insights that could lead to innovative treatments for human diseases. The team will utilize advanced tools and techniques to manipulate and measure G protein activity, enhancing our understanding of how these proteins function in different contexts.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapeutic strategies targeting G protein signaling pathways, potentially improving treatment options for various diseases.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling, indicating that this approach has the potential for significant advancements in medical treatment.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Garcia-Marcos, Mikel — Boston University Medical Campus
- Study coordinator: Garcia-Marcos, Mikel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.