Understanding how FUS protein behaves in neurodegenerative diseases
Residue-by-residue details of FUS protein phase separation and aggregation
This study is looking at a protein called FUS that plays an important role in our cells, and it's trying to understand how certain parts of this protein can cause problems that might lead to diseases like ALS and frontotemporal dementia, with the hope of finding new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10918269 on NIH RePORTER |
What this research studies
This research investigates the behavior of the FUS protein, which is involved in critical cellular processes like RNA metabolism. It focuses on how certain disordered regions of the FUS protein can lead to abnormal protein assembly, contributing to diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). By examining the molecular interactions and roles of these disordered domains, the research aims to uncover mechanisms that could lead to new therapeutic strategies. Patients may benefit from insights gained about the underlying causes of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
Not a fit: Patients with neurodegenerative diseases not related to FUS protein dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases like ALS and FTD.
How similar studies have performed: Other research has shown promising results in understanding protein behavior in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Fawzi, Nicolas Lux — Brown University
- Study coordinator: Fawzi, Nicolas Lux
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.