Understanding how fungi resist medicines
ATP Binding Cassette (ABC) Transporters in Fungal Drug Tolerance
This project aims to understand how common fungal infections, like Candida, become resistant to antifungal medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11126579 on NIH RePORTER |
What this research studies
Fungal infections can be hard to treat because the fungi develop ways to resist medicines. This project focuses on special proteins within fungi, called ABC transporters, which help them get rid of drugs or change their shape to survive. By studying these proteins at a detailed level, including their structure and how they work inside fungal cells, we hope to learn why current antifungal treatments sometimes fail. The goal is to find new ways to overcome this resistance and make treatments more effective.
Who could benefit from this research
Good fit: Patients with serious fungal infections, especially those caused by Candida species, who experience drug resistance, could potentially benefit from future therapies developed from this research.
Not a fit: Patients with non-fungal infections or those whose fungal infections respond well to existing treatments may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective treatments for fungal infections that are currently resistant to medicines.
How similar studies have performed: This project builds on preliminary work identifying key features of how these fungal transporters are regulated during stress, suggesting a foundation for further investigation.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Tomasiak, Thomas Michael — University of Arizona
- Study coordinator: Tomasiak, Thomas Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.