Understanding how fungi move from the blood to the brain.
The molecular basis for the translocation of fungi from blood-to-brain.
This study looks at how certain fungi, like Candida albicans, can get into the brain and cause infections, especially in people with weakened immune systems, to help us understand how these infections happen and how to better protect against them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10771097 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which certain fungi, such as Candida albicans, can cross the blood-brain barrier and cause infections in the central nervous system. The study focuses on the interactions between fungal cells and specific receptors in the brain's blood vessels, aiming to uncover the molecular pathways that facilitate this translocation. By examining these processes, the research seeks to provide insights into how fungal infections can lead to severe neurological conditions. Patients with compromised immune systems may particularly benefit from the findings of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with weakened immune systems, such as those living with AIDS or other immunocompromising conditions.
Not a fit: Patients with fungal infections not affecting the central nervous system may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating fungal infections in the brain, significantly improving patient outcomes.
How similar studies have performed: Previous research has shown success in understanding fungal infections and their mechanisms, but this specific approach to studying blood-brain barrier translocation is relatively novel.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Gelli, Angie — University of California at Davis
- Study coordinator: Gelli, Angie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.